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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Hedgehog Signal transduction Pathway Inhibitors + Pyrimidines & Acute myeloid leukemia (AML)

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Glasdegib is a validated oral SMO inhibitor. Glasdegib + low-dose cytarabine is the strongest clinically established link between a Hedgehog pathway inhibitor and a pyrimidine analog in Acute myeloid leukemia (AML). Hedgehog signaling, particularly through Smoothened (SMO), a component of the Hedgehog (Hh) pathway, is linked to:

(1) Jamieson et al. 2020 Blood Cancer Discov 1(2): 134-145
(2) La…

Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia
Jamieson et al. 2020 Blood Cancer Discov 1(2): 134-145
Review
Understanding the Hedgehog Signaling Pathway in Acute Myeloid Leukemia Stem Cells: A Necessary Step toward a Cure
Lainez-González et al. 2021 Biology (Basel) 10(4): 255
Review

7/1/2026