XXX-1 - VSL#3 vs Placebo & Diarrhea / Diarrhoea (radiation-induced) (Prevention)

Background:

Radiotherapy targeting the pelvic area can cause a severe side-effect known as diarrhoea. This occurs due to acute enteric damage. (2)

Study overview:

A double-blind, placebo-controlled trial evaluating the probiotic preparation VSL#3 TM (one sachet t.i.d. ,) or placebo starting from the first day of radiation therapy in 490 patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer (1)

Primary outcome measures:

Incidence and severity of radiation-induced diarrhea (1)

Results:

In the study, it was observed that a higher number of patients receiving a placebo experienced radiation-induced diarrhea compared to those receiv…