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Hepatitis B virus (HBV) is a well-established cause of hepatocellular carcinoma (HCC).
The process by which Hepatitis B Virus (HBV) induces cancer, also known as oncogenesis or tumorigenesis, is multifaceted and involves both direct and indirect mechanisms.
The integration of HBV DNA into the host genome is a critical early event in the development of HCC. This integration can lead to chromosomal instability and the alteration of cancer-related genes. It has been shown that HBV DNA integration affects a variety of cancer-related genes and exerts insertional mutagenesis
Lupberger & Hildt 2007 …