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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Autoimmunity & Follicular B Helper T Cells (Tfh)

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An excessive Follicular B Helper T Cells (Tfh) response can result in the overproduction of autoantibodies, leading to autoimmune conditions. Therefore, it is crucial to have a counter-regulator for the Tfh cell response to prevent such overproduction
Linterman et al. 2009 J Exp Med 206: 561-576
Ueno et al. 2015 Nat Immunol 16: 142-152(brain://AQfBFILM7lSsLKZx0WyfBg/Cd4CellsTHelferzellenTHelperCells)
Deng et al. 2019 Nat Rev Rheumatol 15: 475-490

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References (Sources)

Follicular helper T cells are required for systemic autoimmunity
Linterman et al. 2009 J Exp Med 206: 561-576
Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells
Teng et al. 2016 Immunity 44: 875-888
Pathophysiology of T follicular helper cells in humans and mice
Ueno et al. 2015 Nat Immunol 16: 142-152
Review
Spatial and functional heterogeneity of follicular helper T cells in autoimmunity
Seth & Craft 2019 Current Opinion Immunology 61: 1-9
Review
T follicular helper cells and T follicular regulatory cells in rheumatic diseases
Deng et al. 2019 Nat Rev Rheumatol 15: 475-490
Review
T Follicular Helper Cells Regulate Humoral Response for Host Protection against Intestinal Citrobacter rodentium Infection
Bai et al. 2020 J Immunol 204: 2754

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Autoimmunity & Follicular B Helper T Cells (Tfh)

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