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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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Alfa-Hemolysin / Hemolysin A (HlyA)

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Staphylococcal alfa-hemolysin is an essential virulence factor

The Escherichia coli hemolysin A (HlyA) transport system has long been used as a model to study Type I Secretion Systems (T1SS)
Holland et al. 2005 Mol. Membr. Biol. 22: 29-39
Thomas et al. 2014 Biochim. Biophys. Acta 1843: 1629-1641

Alfa-Hemolysin / Hemolysin A (HlyA) is secreted in an unfolded state from the cytosol to the extracellular space (Koronakis et al. 1989 EMBO J. 8: 595-605; Thomas et al. 2014 Biochim. Biophys. Acta 1843: 1629-1641), where…

References (Sources)

Isolation and analysis of the C-terminal signal directing export of Escherichia coli hemolysin protein across both bacterial membranes
Koronakis et al. 1989 EMBO J. 8: 595-605
Plasmid cistrons controlling synthesis and excretion of the exotoxin alpha-haemolysin of Escherichia coli
Noegel et al. 1979 Mol. Gen. Genet. 175: 343-350.
The binding of divalent cations to Escherichia coli alpha-haemolysin
Ostolaza et al. 1995 Eur. J. Biochem. 228: 39-44
The calcium-binding C-terminal domain of Escherichia coli alpha-hemolysin is a major determinant in the surface-active properties of the protein
Sánchez-Magraner et al. 2007 J. Biol. Chem. 282: 11827-11835
The type 1 secretion pathway—the hemolysin system and beyond
Thomas et al. 2014 Biochim. Biophys. Acta 1843: 1629-1641
Review
TolC, an Escherichia coli outer membrane protein required for hemolysin secretion
Wandersman & Delepelaire 1990 Proc. Natl. Acad. Sci. USA 87: 4776-4780
Type 1 protein secretion in bacteria, the ABC-transporter dependent pathway (review)
Holland et al. 2005 Mol. Membr. Biol. 22: 29-39
Review

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