Immunity & Multiple sclerosis (MS)

APCs (DCs, macrophages, B cells) and T cells first interact in the periphery, leading to activation and dysregulation of peripheral immunity and the secretion of inflammatory molecules
Charabati et al. 2023 Cell 186(7): 1309

At its core, MS is both an inflammatory and a neurodegenerative disease. It is predominantly driven by the immune system's attack on the myelin sheath, the protective covering of nerve fibers. This attack is orchestrated by specific immune cells: CD4+ T helper 1 (Th1) cells, CD4+ T helper 17 (Th17) cells, CD8+ T cells, and B cells. Among these, CD4+ Th1 and CD4+ Th17 cells have been the focus of extensive research, particularly in the context of MS and its animal model, experimental autoimmune e…