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Paclitaxel poliglumex (PPX) is a drug conjugate that links paclitaxel to a biodegradable, water-soluble polyglutamate polymer. It has been developed to overcome the dose-limiting side effects of solvent-based paclitaxel, particularly peripheral neuropathy. PPX increases the water solubility of paclitaxel, allowing the delivery of higher doses than those achievable with paclitaxel alone
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