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Pluripotency refers to the unique ability of certain stem cells to differentiate into nearly any cell type of the body.
The maintenance of pluripotency is regulated by a network of transcription factors, among which Oct-4, Sox2, and Homeobox protein NANOG play pivotal roles.
These core factors not only sustain the self-renewal and undifferentiated state of pluripotent stem cells but also regulate the expression of other pluripotency-associated genes while repressing lineage-specific genes.
see also:
[Human pluripotent stem cells (hPSC…