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Anti-CTLA-4 / CTLA-4 antibodies in cutaneous melanoma mainly refers to ipilimumab, a monoclonal antibody that blocks CTLA-4 on T cells and thereby releases an inhibitory immune checkpoint to enhance anti-tumor immunity. Historically, CTLA-4 blockade was one of the first checkpoint strategies to show durable tumor regressions in metastatic melanoma, but in current practice it is used less often as monotherapy than PD-1 blockade because it is generally less active and more toxic
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