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Liver tissue-resident Innate-like T cells (ILTCs) are abundant, self-renewing, and long-lived in humans and mice. They patrol the liver sinusoids, sensing cytokines and stress ligands to secrete pro-inflammatory or tissue-protective factors. Their context-dependent functions range from cytokine-mediated inflammation to tissue repair, which can also lead to fibrosis and cirrhosis. ILTCs function as a multilayered network that adapts to liver disease.
References:
Boismenu & Havran 1…