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The ENS, often referred to as the “second brain", is the largest and most complex unit of the peripheral nervous system and is located within the walls of the GI tract, extending from the esophagus to the anal canal (4, 5). Additionally, it is a major player in the gut-brain axis which is a bidirectional communication system between the [central nervous system (CNS)](brain://api.thebrain.com/wzsof…