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Dendritic cells (DCs) play crucial roles in both innate and adaptive immunity, and they can induce antigen-specific tolerance in central and peripheral lymphoid organs. In the thymus, DCs promote tolerance by eliminating self-reactive T cells. In peripheral organs, they induce tolerance by capturing antigens and presenting them on MHC class I and II molecules. In a steady state, low antigen doses lead to T cell deletion and unresponsiveness. However, if DC maturation stimuli are present, immunity develops with effector an…