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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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T helper 17 cell (Th17) & Tumor Necrosis Factor alfa (TNF-alfa)

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T helper 17 cell (Th17) and Tumor Necrosis Factor alfa (TNF-alfa) are closely linked in inflammatory and autoimmune diseases. Tumor Necrosis Factor alfa (TNF-alfa) which is produced in T helper 17 cell (Th17), thereby increases their pathogenicity and differentiation. T helper 17 cell (Th17) can also induce the production of Tumor Necrosis Factor alfa (TNF-alfa) in macrophages.

References:

Huang et al. 2021f Front Immunol. 12:593473

Sosa-Jurado et al. 2021 Eur Cytokine Netw. 32(2): 23-30

Muench et al. 2022 J Immunol. 208(6): 1315-1328…

References (Sources)

A Pathogenic Th17/CD38+ Macrophage Feedback Loop Drives Inflammatory Arthritis through TNF-α
Muench et al. 2022 J Immunol. 208(6): 1315-1328
miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases
Huang et al. 2021f Front Immunol. 12:593473
Review
Serum Th17 and TNF-α distinguish between patients with occult hepatitis B infection, chronic hepatitis B infection and healthy individuals
Sosa-Jurado et al. 2021 Eur Cytokine Netw. 32(2): 23-30
TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity
Schick et al. 2020 J Immunol 205: 323

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T helper 17 cell (Th17) & Tumor Necrosis Factor alfa (TNF-alfa)

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