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In mouse experiments, Deoxycholic Acid (DCA) dose-dependently induces NLRP3 inflammasome activation and production of potent pro-inflammatory cytokine Interleukin-1 (IL-1) beta (IL-1F2) in macrophages.
Mechanistically, Deoxycholic Acid (DCA) triggered NLRP3 inflammasome activation via cathepsin B release, at least in part via sphingosine-1-phosphate receptor 2.
High concentrations of Deoxycholic Acid (DCA) in stool may se…