Aromatase inhibitors & Endometriosis

Based on the critical role of estrogens and the rate-limiting step in the production of the estrogens represented by the aromatase enzyme, Aromatase inhibitors are a potential therapeutic option for women affected by endometriosis. Nevertheless, further research is needed to clarify the efficacy of Aromatase inhibitors in this setting. Adverse effects need to be investigated to clarify the preventive role of add-back therapy. On that basis, Aromatase inhibitors should be adopted only as second-line therapy in patients who are refractory to standard treatments in the setting of scientific research. Further studies should de…