Amyloid-beta (Aß, Abeta) / Amyloid Plaques

Amyloid Plaques Define Alzheimer’s Disease Pathology

Senile plaques are deposits of amyloid-beta that accumulate in the brain. They are one of the defining neuropathological markers of Alzheimer’s disease, alongside neurofibrillary tangles (NFTs) (1). These plaques may disrupt neuronal health and signaling, contributing to brain dysfunction and symptoms such as impaired memory (1, 3).

Oxidative Stress and Autophagy Shape Neurodegeneration

Senile plaques and NFTs are associated with oxidative stress, [inflammation](brain://api.thebrain.com/wzsofVOsh4ANI-lTZFbXX…