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Chimeric antigen receptor (CAR) T-cell associated cytokine release syndrome (CRS) may present with tachycardia, hemodynamic instability and reduced cardiac function.
Cardiac toxicity was generally reversible by day 28 post-infusion. More frequent monitoring with formal echocardiograms, with systemic analysis of changes in left ventricle global longitudinal strain (GLS) and cardiac biomarkers (troponin and proBNP) may help identify earlier the patients at highest risk of severe cardiac systolic dysfunction
see also:
Adverse Events / Safety & CD19 CAR-T…