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Suzetrigine is an oral non-opioid analgesic designed for managing moderate-to-severe acute pain in adults. According to several reviews from 2025, it is explicitly recognized as an FDA-approved selective NaV1.8 sodium channel inhibitor for the treatment of moderate-to-severe acute pain (1, 2, 3, 4, 5, 6, 7)
The two randomized, double-blind, placebo- and active-controlled clinical phase III treatment trials, identified as NCT05553366 (NAVIGATE 1) and NCT05558410 (NAVIGATE 2), demonstrated that suzetrigine effectively reduced moderate to severe acute pain over a 48-hour period fol…