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The clinical trial NCT03710850 is a study related to the modification of the gut microbiota in the treatment of insulin resistance. The trial aims to personalize the approach to treating insulin resistance by modifying the gut microbiota. The study involves analyzing the gut microbiome and its response to dietary inulin. Forty-nine patients with newly diagnosed pre/diabetes (DM), 66 metabolically healthy overweight/obese (OB), and 32 healthy lean (LH) volunteers were compared in a cross-sectional case-control study integrating clinical variables, dietary intake, gut microbiome, and fecal/serum metabolomes (16 S rRNA sequencing, metabolomics profiling). Subsequently, 27 DM were recruited for a predictive study: 3 months of dietary inulin (10 g/day) intervention.
Primary outco…