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Pemetrexed is a type of antifolate known as pyrrolopyrimidine. It works by inhibiting enzymes such as thymidylate synthase, glycinamide ribonucleotide formyltransferase, and dihydrofolate reductase.
see also:
Dihydrofolate reductase (DHFR) inhibitors
Thymidylate synthase inhibitors
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