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Insertion mutations in Erb-b2 receptor tyrosine kinase 2 gene (ERBB2 or HER2) exon 20 occur in 2%-5% of NSCLC and function as an oncogenic driver.
Le et al. 2022 J Clin Oncol 40: 710-718
HER2 exon 20 insertions and point mutations are oncogenic drivers found in 1%-2% of patients with NSCLC. No targeted therapy is approved for this subset of patients
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