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Microbiome analysis was performed to identify differences between adult and aged mice at baseline. β-diversity analysis revealed that gut microbiota composition was different between adult (3–6 months) and aged (22–25 months) mice fed a normal chow diet (PERMANOVA p < 0.05). RF analysis with Boruta feature selection identified [lower levels of Mucuspirillum spp. and Odoribacter spp., and higher levels of in Ruminococcus spp., Coprococcus spp., and Rikenellaceae in aged versus adult mice](brain://QEoII74BXkuu3Lz22uSVbQ/LowerLevelsOfMucuspirillumSppAndOdoribacterS…