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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Probiotics (living agents) & Stress

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Raised levels of circulating corticosterone in germ-free rodents (Crumeyrolle-Arias et al. 2014 Psychoneuroendocrinology 42: 207-217) are reduced following the administration of probiotics (Sudo et al. 2004 J Physiol 558: 263-275), an effect replicated in mice subjected to a stress-inducing behavioral paradigm designed to elevate corticosterone levels
Bravo et al. 2011 Proc. Natl. Acad. Sci. USA 108: 16050–16055
Schmidt et al. 2015a Psychopharmacology (Berl.) 232(10): 1793-1801

Zhang et al. (2020s) evaluated 7 randomized clinical studies in which probiotics' influence on stress symptoms was examined. The authors' conclusion was: Probiotic administration could reduce subjective stress levels in healthy v…

References (Sources)

Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats
Crumeyrolle-Arias et al. 2014 Psychoneuroendocrinology 42: 207-217
Effects of probiotics on depressive or anxiety variables in healthy participants under stress conditions or with a depressive or anxiety diagnosis: A meta-analysis of randomized controlled trials
Chao et al. 2020 Front. Neurol.11: 421
Meta-Analysis
Review
Efficacy of probiotics on stress in healthy volunteers: A systematic review and meta-analysis based on randomized controlled trials
Zhang et al. 2020s
Meta-Analysis
Review
Ingestion of lactobacillus strain regulates emotional behavior and central gaba receptor expression in a mouse via the vagus nerve
Bravo et al. 2011 Proc. Natl. Acad. Sci. USA 108: 16050–16055
Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice
Sudo et al. 2004 J Physiol 558: 263-275
Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models
Takada et al. 2016 Neurogastroenterol. Motil. 28(7): 1027-1036
Probiotic supplementation improves cognitive function and mood with changes in gut microbiota in community-dwelling elderly: a randomized, double-blind, placebo-controlled, multicenter trial
Kim et al. 2021j J Gerontol A Biol Sci Med Sci 76(1): 32-40

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