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The results reveal that Segatella copri, which is positively associated with weight-for-length Z score (WLZ), is the principal contributor to MDCF-2-induced expression of metabolic pathways involved in utilizing the component glycans of MDCF-2. The predicted specificities of carbohydrate-active enzymes expressed by their Polysaccharide utilization loci (PULs) are correlated with: