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ST6Gal-I sialyltransferase (ST6Gal-I) plays a significant role in carcinogenesis through its involvement in aberrant glycosylation, a universal feature of cancer cells. This enzyme catalyzes the addition of alfa2,6-linked sialic acids onto terminal N-glycans, a modification that is upregulated in numerous types of cancer, including pancreatic, prostate, breast, and ovarian cancer. The altered expression of ST6Gal-I and the resulting abnormal sialylation have been linked to various aspects of [tumor progre…