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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Merkel-cell carcinoma (MCC) & Drugs/Treatments

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The standard therapy for Merkel Cell Carcinoma (MCC) has evolved in recent years, with immune checkpoint inhibitors becoming the primary treatment for advanced cases

For patients with advanced or metastatic Merkel-cell carcinoma (MCC), anti-PD-1/PD-L1 immune checkpoint inhibitors have become the standard of care. The most commonly used agents are:

Pembrolizumab (anti-PD-1)

Avelumab (anti-PD-L1)

Gehrcken et al. 2021 Int J Mol Sci. 22(16): 8679

see also:
Immune Checkpoint Inhibitors (ICIs) & Merkel-cell carcinoma (MCC)
[Avelumab & Merkel Cell Carcinoma (MCC)](brain://HADbZ0L…

References (Sources)

How we treat Merkel cell carcinoma: within and beyond current guidelines
Park et al. 2021
Real-world outcomes among US Merkel cell carcinoma patients initiating immune checkpoint inhibitors or chemotherapy
Chandra et al. 2020
Recent Therapeutic Advances and Change in Treatment Paradigm of Pts with Merkel Cell Carcinoma
Garcia-Carbonero et al. 2019 The Oncologist 24: 1375-1383
Systematic literature review of current treatments for stage I–III Merkel cell carcinoma
Palencia et al. 2021 Future Oncol. 17(34): 4813-4822
Review
T-Cell Responses in Merkel Cell Carcinoma: Implications for Improved Immune Checkpoint Blockade and Other Therapeutic Options
Gehrcken et al. 2021 Int J Mol Sci. 22(16): 8679
Review

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7/1/2026

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Merkel-cell carcinoma (MCC) & Drugs/Treatments

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