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ABSTRACT
Introduction: As a protein-based biomaterial for potential cancer targeting delivery, apoferritin has recently attracted interest.
Areas covered: In this review, we discuss the development of this cage-like protein as an endogenous nanocarrier that can hold molecules in its cavity. We present the specific characterizations and formulations of apoferritin nanocarriers, and outline the recent progress of the protein as an appro- priate tumor-delivery vehicle in different therapeutic strategies to treat solid tumors. Finally, we propose how the application for cancer drug repurposing delivery within apoferritin could expand cancer treatment in the future.
Expert opinion: Being a ubiquitous iron storage protein that exists in many living organisms, apoferri- tin is promising as a cancer tumor-targeting…