Lymphoid Tissue Inducer Cells (LTi cells)

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LTi Cells Build Secondary Lymphoid Organs

Lymphoid Tissue Inducer (LTi) cells are a specialized subset of group 3 innate lymphoid cells (ILC3s). They are crucial for developing secondary lymphoid organs, including lymph nodes and Peyer’s patches. LTi cells also support the activation and function of T and B cells. Their distinct gene-expression profile, developmental origin, and functions distinguish them from other [ILCs](brain://api.thebrain.com/…

References (Sources)

CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
Sonnenberg et al. 2011 Immunity 34:122–134.
Innate lymphoid cells: potential targets for cancer therapeutics
Ng & Belz 2023 Trends in Cancer 9(2): 158-171
Review
Lymphoid tissue inducer — a divergent member of the ILC family
Zhong et al. 2018 Cytokine Growth Factor Rev. 42: 5-12
Prescott’s Microbiology
Willey et al. 2023 McGraw Hill, USA, ISBN 978-1-265-12303-1
Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes
Vonarbourg et al. 2010

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