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Tissue anti-inflammatory macrophages are crucial for maintaining local intestinal homeostasis. They achieve this by eliminating apoptotic or senescent cells and aiding in tissue remodeling (1, 2).
Chronic or excessive tissue repair can cause fibrosis, which can lead to organ failure and death (3).
The proper regulation of CD4+ Th2 cells is crucial and ensures tissue repair without fibrosis (3).
Inflammation-induced u…