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Kynurenine (Kyn) is an agonist of the Aryl Hydrocarbon Receptor (AhR) that, once activated, can lead to additional upregulation of Indoleamine 2,3-Dioxygenase (IDO), thus creating a positive feedback loop
The tryptophan catabolite, kynurenine, activates the aryl hydrocarbon receptor (AHR), which in turn promotes tumor immune escape.
Opitz et al. 2011 Nature. 478: 197-203
Kynurenine, produced by the enzyme indoleamine 2,3-dioxygenase (IDO), acts as an endogenous ligand for AHR, leading to the suppression of antitumor immun…