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Akkermansia muciniphila has been identified as having an impact on colorectal cancer pathogenesis. Studies show a significant reduction in A. muciniphila abundance in colorectal cancer patients across two independent clinical cohorts and the GMrepo dataset.
Supplementing with A. muciniphila has been found to suppress colonic tumorigenesis in ApcMin/+ mice and inhibit the growth of implanted HCT116 or CT26 tumors in nude mice.
Mechanistically, Akkermansia muciniphila promotes the enrichment of M1-like macrophages through an NLRP3-dependent mechanism both…