Occurrence of acquired interbacterial defense (AID) gene clusters in Bacteroidales residing within the human gut microbiome. These clusters encode arrays of immunity genes that protect against T6SS-mediated intra- and inter-species bacterial antagonism
Ross et al. 2019b Nature 575: 224–228
The orphan immunity genes of multiple Bacteroides spp. – localized to AID systems – can confer protection against effectors delivered by the T6SS of B. fragilis
Ross et al. 2019b Nature 575: 224–228
Homologs of B. fragilis T6S immunity genes i6 and i7 are located together within discrete gene clusters, which we termed AID-1 (acquired interbacterial defense 1) systems, in several Bacteroides strains
Ross et al. 2019b Nature 575: 224–228
in both B. ovatus and B. fragilis, AID-1 system genes grant immunity against corresponding T6S effectors
Ross et al. 2019b Nature 575: 224–228