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After Peptide vaccinatlon T cells are generated that respond to Peptides that were not in the original vaccine
formulation indicating that a secondary round of T cell priming has occurred with antigens taken directly from tumour cells (in: Vanneman & Dranoff, 2012)
That is, new-CTL clones against previously ignored antigens
Corbière et al., 2011
Antigen Spreading Contributes Decisively to Tumor Regression
Corbière et al., 2011…