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Carbohydrate Antigen 19-9 (CA19-9) is a biomarker that is elevated in a substantial group of patients with pancreatic ductal adenocarcinoma (PDAC) but has limitations in terms of accuracy.
Sialylated tumor-related antigen (sTRA), a glycan also known as sialyl-di-Lewis-A glycoproteins (Lea), has been identified as a potential biomarker for PDAC that could improve upon the accuracy of CA19-9 in the diagnosis of pancreatic cancer.
Research has shown that sialyl-di-Lewis-A glycoproteins (Lea) is produced and secreted by pancreatic tumors and models that do not produce CA19-9, indicating that…