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Caplacizumab is FDA approved for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP). It has been shown to be effective and safe in the management of aTTP, including in pregnant patients and those with refractory disease.
A systematic review and meta-analysis found that caplacizumab significantly reduced all-cause mortality in Thrombotic thrombocytopenic purpura patients and did not significantly increase the risk of major bleeding or Thrombotic thrombocytopenic purpura relapse compared to standard care
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