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Fusions in the neuregulin 2 (NRG2) genes are significant molecular features of non-small cell lung cancer (NSCLC)
These genetic rearrangements lead to enhanced ectopic expression of the NRG/ErbB receptor-ligand, which subsequently triggers downstream signaling pathways. There is substantial evidence suggesting that deregulation of the NRG1/ErbB3 axis plays a crucial role in the progression of NSCLC and contributes to treatment resistance.
NRG1 and NRG2 fusions should be considered novel markers for biological therapies targeting the ErbB2/ErbB3 receptors. There is compelling evidence linking the deregulation of the NRG1/ErbB3 axis to the cancer stem cell ph…