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Loss of REG3 family members compromises the integrity of the intestinal barrier
However, overproduction of REG3 proteins can also be detrimental by reducing a protective species in the microbiota
Patients with inflammatory bowel disease (IBD) experiencing flares displayed heightened levels of secreted REG3 proteins that mediated depletion of Enterococcus faecium from the gut microbiota
[Enterococcus faecium](brai…