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Commensal bacteria in the colon may play a role in
colorectal cancer (CRC) development. Recent studies from
North America showed that Fusobacterium nucleatum (Fn)
infection is over-represented in disease tissue versus matched
normal tissue in CRC patients. Using quantitative real-time
polymerase chain reaction (qPCR) of DNA extracted from
colorectal tissue biopsies and surgical resections of three
European cohorts totalling 122 CRC patients, we found an
over-abundance of Fn in cancerous compared to matched
normal tissue (p<0.0001). To determine whether Fn infection
is an early event in CRC development, we assayed Fn in
colorectal adenoma (CRA) tissue from 52 Irish patients.
While for all CRAs the Fn level was not statistically
significantly higher in disease versus normal tissue (p=
0.06), it wa…