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Infigratinib represents a promising agent in the treatment of refractory intrahepatic cholangiocarcinoma (ICCA) with FGFR2 fusions and is uniquely positioned to be a potential option in chemonaive patient populations. An ongoing phase III trial (PROOF-301) compares the efficacy and safety of infigratinib versus standard gemcitabine and cisplatin in untreated patients with intrahepatic cholangiocarcinoma (ICCA) and FGFR2 fusions.
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