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Entospletinib is an oral, selective Tyrosine-Protein Kinase SYK Inhibitor / Spleen tyrosine kinase (Syk) Inhibitor, which is involved in the BCR Signal transduction pathway. It has shown clinical activity in patients with relapsed or refractory CLL, including those with Richter's transformation, who had received prior therapy with B-cell receptor (BCR) inhibitors.
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