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This molecule has been associated with co-stimulatory as well as co-inhibitory functions in regulating T cell responses in CD4+ and CD8+ cells
These effects of T cell co-stimulation or co-inhibition by the same molecule could be due to multiple receptors, presence of other co-stimulatory or co-inhibitory molecules or the presence of different immune cells / cytokines leading to modulation of B7-H3 function
The B7-H3 receptor has not yet been identified
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