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ILCs are similar to T cells (CD4 +helper T (Th) cells and CD8 +cytotoxic T (Tc) cells), although they lack antigen-specific receptors. ILCs consist of five subgroups - ILC1, ILC2, ILC3, Lymphoid Tissue Inducer (LTi-like) cells, and Natural Killer (NK) cells defined mainly by the intrinsic transcription factors expressed and the cytokines produced by each subgroup. ILCs respond instantly to signals from internal and external sources. New findings have shown that micronutrients in food, such as various vitamins and minerals, can significantly modulate the immune response through ILCs and subsequently affect human health. Micronutrients have been shown to control the development and reproduction of different types of ILCs. They are also powerful immune regulators in several autoimmune diseases and play an importa…