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Particularly, one of the most widely occurred tumor-associated glycan structure is the complex beta 1,6-GlcNAc–branched N-glycans
Taniguchi et al. 2015 Adv Cancer Res 126:11–51
ST6GAL I is the main sialyltransferase responsible for alfa2, 6-linked Sialic Acids formation on N-glycans, which is highly associated with poor outcomes
ST6Gal 1 Sialyltransferase (ST6Gal-I) is upregulated in several types of epithelial cancers, but not non-epithelial cancers
Among the most common alterations in …