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Alfa-mannans can be identified by TLRs and C-type lectin receptors (Dectin1, Dectin-2 (CLEC6A), and Macrophage-inducible C-type lectin (MINCLE / CLEC4E))
Alfa-mannans stimulates Dectin-2 (CLEC6A). After recognition, spleen tyrosine kinase (SYK) and caspase recruitment domain family member 9 (CARD9) were activated, thereby activating the NF-kB pathway, releasing pro-inflammatory cytokines, and inducing inflammatory response
Alfa-mannans consist of mannose monomers linked primarily by alfa-(1→2), alfa-(1→3), or alfa-(1→6) glycosidic bonds, forming a key component of fungal and yeast cell walls recognized by receptors like Dectin-2, differing from plant beta-mannans. They resist human digestion but are microbiota substrates.