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Erlotinib and gemcitabine, as an example for ErbB1 / HER-1 / EGFR tyrosine kinase inhibitors + Pyrimidines, work well together for pancreatic cancer. This combination showed a small but significant survival benefit. It was proven in a phase III trial for advanced pancreatic cancer. Other similar drug combinations have not been as successful. Most remain in early testing or have not shown positive results.
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