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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Cerebion E3 ligase modulators (CELMoD)

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CELMoDs represent a novel therapeutic strategy that co-opts the ubiquitin-proteasome system to degrade specific cancer-driving proteins, offering a promising approach for treating hematological malignancies and potentially other diseases.
Charliński et al. 2021 Cancers (Basel) 13(18): 4666
Richardson et al. 2022 Expert Rev Proteomics 19(4-6): 235-246
Watson et al. 2022 Science 378(6619): 549-553…

References (Sources)

Molecular glue CELMoD compounds are regulators of cereblon conformation
Watson et al. 2022 Science 378(6619): 549-553
Rapid Progress in the Use of Immunomodulatory Drugs and Cereblon E3 Ligase Modulators in the Treatment of Multiple Myeloma
Charliński et al. 2021 Cancers (Basel) 13(18): 4666
Review
The role of E3 ubiquitin ligase in multiple myeloma: potential for cereblon E3 ligase modulators in the treatment of relapsed/refractory disease
Richardson et al. 2022 Expert Rev Proteomics 19(4-6): 235-246
Review

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Cerebion E3 ligase modulators (CELMoD)

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