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Osteosarcoma (OS) is the most common primary bone tumor worldwide.
OS exhibits a range of aggressive behaviors, including early metastasis potential, rapid progression, poor clinical prognosis, and insensitivity to chemoradiotherapy.
Non‑coding RNAs are transcripts that do not encode proteins.
A significant number of studies published on OS have been focused on the aberrant expression of non‑coding RNAs and their involvement in tumor initiation and progression.
It has been confirmed that non‑coding RNAs exert their regulatory functions at both the transcriptional and post‑transcriptional levels, which leads to tumor initiation or progression in OS.
According to present knowledge, this review…