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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Cancer / Tumors & Deoxycholic acid (DCA)

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High concentrations of the secondary bile acid Deoxycholic acid (DCA) have been linked to several cancers.
Plotnikoff 2014 Global Adv Health Med. 3(3): 33-43

Deoxycholic acid (DCA) does not appear to be directly toxic but instead is a promoter of carcinogenesis.
Narisawa et al. 1974 J Natl Canc Inst. 53: 1093-1097
Reddy et al. 1976 J Natl Canc Inst. 56: 441-442

This is likely due to its role as a signaling molecule related to the control of lipid, bile acid, and carbohydrate metabolism.
Baptissart et al. 2013 Biochimie 95: 504-517

Deoxycholic acid (secondary bile acid, DCA) is associated with intestinal carcinogenesis.
Shmuely et al. 2001 Am J Gastroenterol 96(12): 3406-3410

Cao et al. investigated the effect of deoxycholic acid on …

References (Sources)

Bile acids: From digestion to cancers
Baptissart et al. 2013 Biochimie 95: 504-517
Review
Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats
Narisawa et al. 1974 J Natl Canc Inst. 53: 1093-1097
Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats
Reddy et al. 1976 J Natl Canc Inst. 56: 441-442
Relationship between Helicobacter pylori CagA status and colorectal cancer
Shmuely et al. 2001 Am J Gastroenterol 96(12): 3406-3410
The secondary bile acid, deoxycholate accelerates intestinal adenoma-adenocarcinoma sequence in Apc (Min/+) mice through enhancing Wnt signaling
Cao et al. 2014 Fam Cancer 13(4): 563-571
Three Measurable and Modifiable Enteric Microbial Biotransformations Relevant to Cancer Prevention and Treatment
Plotnikoff 2014 Global Adv Health Med. 3(3): 33-43
Review

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