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The term HipA most commonly refers to a bacterial protein kinase involved in antibiotic tolerance and Antibiotic persistence, particularly in Escherichia coli and related bacteria. It the toxin component of the HipBA (HipB + HipA) toxin-antitoxin. HipA is a serine/threonine kinase that, when activated, phosphorylates glutamyl-tRNA synthetase, leading to inhibition of protein synthesis, induction of dormancy, and thus increased tolerance to antibiotics (persistence)
Schumacher et al. 2012 Cell Rep 2(3):…