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Genetic engineering approaches such as CRISPR CAR, SUPRA-CAR, inhibitory CAR (iCAR), and others incorporate built-in safety features to prevent Cytokine Release Syndrome / Cytokine storm (hypercytokinemia) and neurotoxicity. In addition, cytokine-targeting approaches (monoclonal antibodies, receptor antagonists), small-molecule inhibitors, and corticosteroids can be used as therapeutic interventions to counteract toxicities that occur following infusion of immune cell-active immunotherapies.
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